NEOMYCIN B

  • Name:NEOMYCIN B
  • CAS:119-04-0
  • Purity:99%
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Details

NEOMYCIN B Good Manufacturer supply High Quality 119-04-0

  • Molecular Formula:C23H46 N6 O13
  • Molecular Weight:614.651
  • Appearance/Colour:Clear Liquid 
  • Refractive Index:1.6000 (estimate) 
  • Boiling Point:927.1 °C at 760 mmHg 
  • PKA:12.93±0.70(Predicted) 
  • Flash Point:514.5 °C 
  • PSA：353.11000 
  • Density:1.61 g/cm3 
  • LogP:-4.69350 

NEOMYCIN B(Cas 119-04-0) Usage

Biochem/physiol Actions

Neomycin is an aminoglycoside antibiotic, produced by Streptomyces containing a minimum of 85% neomycin B. It acts as a selection agent for prokaryotic cells transformed using the neo selectable marker gene. Neomycin trisulfate is used to study the cytototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts and extraction of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins. This product is recommended for use in cell culture applications at 5 mL/L.Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria

Definition

ChEBI: A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.

General Description

Chemical structure: aminoglycoside

InChI:InChI=1/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

119-04-0 Relevant articles

Characterization of a radical S-adenosyl-l-methionine epimerase, NeoN, in the last step of neomycin B biosynthesis

Kudo, Fumitaka,Hoshi, Shota,Kawashima, Taiki,Kamachi, Toshiaki,Eguchi, Tadashi

, p. 13909 - 13915 (2014)

The last step of neomycin biosynthesis i...

Synthesis of ring II/III fragment of Kanamycin: A new minimum structural motif for aminoglycoside recognition

Zárate, Sandra G.,Bastida, Agatha,Santana, Andrés G.,Revuelta, Julia

, (2019/08/20)

A novel protocol has been established to...

TOTAL SYNTHESIS OF NEOMYCIN B

Usui, Takayuki,Umezawa, Sumio

, p. 133 - 144 (2007/10/02)

Total synthesis of neomycin B, a pseudo-...

The total synthesis of neomycin C

Umezawa,Harayama,Nishimura

, p. 3259 - 3262 (2007/10/02)

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119-04-0 Process route

5-O-<3-O-(2,6-diazido-4-O-benzyl-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl>-1,3,2',6'-tetra-N-(benzyloxycarbonyl)neamine

5-O-<3-O-(2,6-diazido-4-O-benzyl-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl>-1,3,2',6'-tetra-N-(benzyloxycarbonyl)neamine

neomycin B
119-04-0

neomycin B

Conditions
Conditions Yield
With hydrogen; palladium on activated charcoal; In 1,4-dioxane; water; acetic acid; for 26h; Pressure (range begins): 4 ;
65%
neomycin C
66-86-4,119-04-0,58617-08-6

neomycin C

neomycin B
119-04-0

neomycin B

Conditions
Conditions Yield
With sodium dithionite; reduced form of S-adenosyl-L-methionine epimerase C249A mutant; S-Adenosyl-L-methionine; In aq. buffer; at 20 ℃; for 30h; Reagent/catalyst; Glovebox; Enzymatic reaction;

119-04-0 Upstream products

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    neomycin C

  • 25389-98-4
    25389-98-4

    neomycin B sulphate

119-04-0 Downstream products

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    62906-25-6

    hexa N-acetyl-neomycin B

  • 2037-48-1
    2037-48-1

    2-deoxystreptamine

  • 3947-65-7
    3947-65-7

    neomycin A

  • 241820-92-8
    241820-92-8

    hexa-N-Boc neomycin B

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