1-(2-Methoxyphenyl)piperazine

  • Name: 1-(2-Methoxyphenyl)piperazine
  • CAS: 35386-24-4
  • Purity: 99%
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1.What is the 1-(2-Methoxyphenyl)piperazine ?

1-(2-Methoxyphenyl)piperazine can be used:To functionalize pyrazolylvinyl ketones via Aza-Michael addition reaction.To prepare cyclic amine substituted Tr?ger′s base derivatives.To prepare functionalized bis(mercaptoimidazolyl)borates by reacting with the activated ester, [(1-methyl-2-mercaptoimidazol-5-yl)carbonyl]succinimide.

methoxybenzene
100-66-3

methoxybenzene

Selectfluor
140681-55-6

Selectfluor

4-(4-methoxyphenyl)piperazine
38212-30-5

4-(4-methoxyphenyl)piperazine

1-(2-Methoxyphenyl)piperazine
35386-24-4

1-(2-Methoxyphenyl)piperazine

Conditions
Conditions Yield
methoxybenzene; Selectfluor; With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; C20H28N4O2Pd(2+)*2BF4(1-); In acetonitrile; at 23 ℃; for 24h;
With water; sodium thiosulfate; In acetonitrile; at 100 ℃; for 2h; Overall yield = 80 %; regioselective reaction; Sealed tube;
piperazine
110-85-0

piperazine

2-bromoanisole
578-57-4

2-bromoanisole

1-(2-Methoxyphenyl)piperazine
35386-24-4

1-(2-Methoxyphenyl)piperazine

Conditions
Conditions Yield
With sodium t-butanolate; In diethylene glycol dimethyl ether; at 170 ℃; for 0.5h; Microwave irradiation;
79%
With (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthalene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0); In tetrahydrofuran; toluene; at 80 - 90 ℃; for 96h;
10%
With dichlorobis(tri-O-tolylphosphine)palladium; sodium t-butanolate; In toluene; Heating;

2.What is the CAS number for 1-(2-Methoxyphenyl)piperazine ?

The CAS number of 1-(2-Methoxyphenyl)piperazine is 35386-24-4.

More information of 1-(2-Methoxyphenyl)piperazine 35386-24-4 are:

CAS?Number

35386-24-4

Density

1.057 g/cm3

Melting Point

35-40 °C(lit.)

Boiling Point

379.9 °C at 760 mmHg

Flash Point

154 °C

Vapor Pressure

5.68E-06mmHg at 25°C

Refractive Index

n20/D 1.575(lit.)

HS CODE

29349990

PSA

24.50000

LogP

1.49860

Pka

8.98±0.10(Predicted)

3.What are another words for 1-(2-Methoxyphenyl)piperazine ?

Synonyms?for?1-(2-Methoxyphenyl)piperazine 35386-24-4:1-(2-methoxyphenyl)-2,3,5,6-tetrahydropyrazine;D 15157;Piperazine,1-(2-methoxyphenyl)-;1-(2-Methoxyphenyl)-Piperazine;

4.What is the molecular formula of 1-(2-Methoxyphenyl)piperazine?

The chemical formula of ?1-(2-Methoxyphenyl)piperazine is?C11H16N2O which containing 11 Carbon atoms,16 Hydrogen atoms,2 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight of??1-(2-Methoxyphenyl)piperazine?is 192.261.

5.What is 1-(2-Methoxyphenyl)piperazine (35386-24-4) used for?

1-(2-Methoxyphenyl)piperazine is a piperazine derivative that acts as a selective antagonist at D3 receptors, influencing the expression of cocaine-induced conditioned place preference (CPP). It is recognized for its potential therapeutic applications in various neurological and psychiatric disorders due to its improved affinity and selectivity for the dopamine D3 receptor.

InChI:InChI=1/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3/p+1

Relevant articles related to 1-(2-Methoxyphenyl)piperazine:

Article

Source

An integrated approach toward nanobret tracers for analysis of gpcr ligand engagement

Boursier, Michelle E.,Hall, Mary P.,Hurst, Robin,Killoran, Michael P.,Kirkland, Thomas A.,Levin, Sergiy,Machleidt, Thomas,Ohana, Rachel Friedman,Zimmerman, Kristopher

, (2021/05/31)

Mixed er-NHC/phosphine Pd(ii) complexes and their catalytic activity in the Buchwald-Hartwig reaction under solvent-free conditions

Ageshina, Alexandra A.,Sterligov, Grigorii K.,Rzhevskiy, Sergey A.,Topchiy, Maxim A.,Chesnokov, Gleb A.,Gribanov, Pavel S.,Nechaev, Mikhail S.,Asachenko, Andrey F.,Bermeshev, Maxim V.,Melnikova, Elizaveta K.

supporting information, p. 3447 - 3452 (2019/04/30)

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